Unified theory of human and animals aging. Bioenergy concept aging as a disease

О книге

Автор книги - Алексей Фитин. Произведение относится к жанрам научно-популярная литература, публицистика, документальная литература. Оно опубликовано в 2022 году. Книге не присвоен международный стандартный книжный номер.

Аннотация

Aging is caused by the main pathogenic factor initiating this disease – oxygen deficiency in organs and tissues. Hypoxia accelerates the degeneration of the weak link – the sensitive nerve endings of the autonomic nervous system. The sequence of events connected by a network of cause-and-effect relationships and representing the pathogenesis of aging disease is considered. The second etiological factor that determines the pathogenesis of aging disease is local hyperoxia of stem cell niches, which leads to accelerated differentiation of stem cells and, as a result, to age-related depletion of their pools. Within the framework of the Concept, the explanation of known significant facts that characterize this disease, but which have not received a clear explanation within the framework of other hypotheses, is considered. Acquisition of disease status by aging makes it possible not only to actively slow down aging, but also to reverse it.

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1. Part One

One of the principal objects of theoretical research in any department of knowledge is to find the point of view from which the subject appears in its greatest simplicity.
J. W. Gibbs

My Comment to the Epigraph of the Famous Thermodynamicist (Energeticist) Josiah Willard Gibbs

A distinctive feature of biology is the incredible diversity (heterogeneity) of elements and an even greater variety of connections between them. This diversity is manifested at all levels of organization of living things from molecules to social formations.

Obviously, the maximum simplicity of representing such a global phenomenon as aging should not be achieved due to primitive concepts, that is, due to neglect of the complexity of the organism structure.

Obviously, the maximum simplicity of representing such a global phenomenon as aging should not be achieved due to primitive ideas about it, that is, due to neglect of the complexity of its structure. It was energy that turned out to be that golden key, with the help of which I was able to penetrate into the essence of one of the central problems of biology and medicine – aging. Consideration of this complex problem from the standpoint of bioenergetics revealed the very, truly divine simplicity, which made it possible to unravel the complex tangle of numerous facts regarding this phenomenon and predict a number of consequences of energy deficit for the body. I believe that one of the most important results of the bioenergetic approach to aging became the identification of the leading role of the autonomic nervous system in the pathogenesis of this disease.

Science is built up of facts, as a house is built of stones; but an accumulation of facts is no more a science than a heap of stones is a house.

Henri Poincare "Science and Hypothesis", 1902

Introduction. How the Bioenergy Concept of Aging Was Born

In connection with the immense breadth of the topic of aging, which must be presented in the limited space of an analytical review, I will present the Concept practically in a thesis form, linking together the etiology and the main stages of pathogenesis by cause-and-effect relationships. As “test words” in the second part of the review, I will present an explanation within the framework of the Concept of a number of long-known phenomena of aging and the most significant facts characterizing this disease, but which have not received a clear explanation within the framework of other hypotheses.

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